Boffy2025NMPADIPE

Title

Neurovascular Mechanisms in Peripheral Arterial Disease: Impact of Physical Exercise and Cognitive Training
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Authors

Clotilde Boffy, Camille Leroy, Stefano Lanzi, Lucia Mazzolai, Alessandra Lintas

Abstract

Peripheral Arterial Disease (PAD) is characterized by atherosclerosis-induced vascular insufficiency, causing reduced blood flow, intermittent claudication, and, in severe cases, rest ischemia or gangrene. Beyond peripheral effects, PAD impairs neurovascular coupling and cognitive functions, such as working memory and executive processes, due to altered cerebral perfusion and chronic inflammation. This study implements a 12-week dual-intervention protocol combining supervised exercise training (SET) and working memory training (WMT) to address these deficits. SET involves individualized multimodal exercise, while WMT uses the Dual n-Back Task to enhance prefrontal connectivity. Multimodal neuroimaging (EEG, fast optical neuroimaging) assesses neurovascular biomarkers and cognitive outcomes. This approach addresses a gap in longitudinal studies, offering insights into neuroprotection and cognitive rehabilitation for patients with PAD with vascular risk profiles.

KeyPhrases

Neurovascular coupling, Peripheral Arterial Disease, cognitive rehabilitation, supervised exercise training, multimodal neuroimaging.

Dates

Created 2025-05-01, presented 2025-06-05, published 2025-07-18.

Citation

Brainiacs Journal 2025 Volume 6 Issue 1 Edoc YD2D1576B
DOI: 10.48085/YD2D1576B
PDP: Nexus/Brainiacs/Boffy2025NMPADIPE
URL: BrainiacsJournal.org/arc/pub/Boffy2025NMPADIPE