Taswell2026EPSMS

Title

The EPSMS Pathway: Immuno-Neuro-PET with Theranostics as a Research Framework to Find a Cure for Multiple Sclerosis
View PDF | Save PDF

Authors

Carl Taswell, David Jordan, Dafang Wu, Stephen Lokitz, Harshad Kulkarni, John Prior and the EPSMS Community

Affiliations

Brain Health Alliance Virtual Institute, Ladera Ranch, California, USA

Abstract

The EPSMS Pathway envisions immuno-neuro-PET with theranostics as a research framework to find a cure for multiple sclerosis. Brain Health Alliance will continue development for this pathway with a research agenda over the next 10 years to build web-enabled platform support, de-identified image data repositories, knowledge engineering, and international collaboration on sequential phases of a multi-site clinical trial for PET medical imaging with an emphasis on standardization and harmonization across multiple sites. This report currently focuses on the initial exploratory phase for the next 3 years, known as the EPSMS Clinical Trial with Entire-body PET Scans for Multiple Sclerosis, as a multi-site clinical trial that is already in progress. The present phase of EPSMS aims to (1) assess the differences in uptake of FDA-approved amyloid imaging radiotracers in normal, demyelinated, and remyelinated white matter in the nervous system between MS patients and healthy subjects, and (2) explore the psychological effects on participants when informed about their imaging results. Future phases of the EPSMS Pathway will investigate the use of PET imaging radiotracers for immune system biomarkers and the potential of theranostics to ameliorate the dysregulation of the immune system that occurs in multiple sclerosis as an auto-immune disorder. Thus, the importance of entire-body medical imaging remains paramount in order to visualize the immune system and monitor biomarkers in the bone marrow, thymus, spleen, lymph nodes and lymphatic system.

KeyPhrases

Multiple sclerosis, auto-immune disorders, neurodegenerative disorders, entire-body PET scans, immuno-neuro-PET, theranostics, EPSMS.

Dates

Created 2026-01-09, updated 2026-01-26, published 2026-03-02, revised 2026-03-24.

Citation

Brainiacs Journal 2026 Volume 7 Issue 1 Edoc LA7A7171C
DOI: 10.48085/LA7A7171C
NPDS: LINKS/Brainiacs/Taswell2026EPSMS

Reviews